Laurie C. Haws, ToxStrategies Inc.

Félix Carvalho, Universidade do Porto, Portugal

Each year the SOT Annual Meeting includes a debate in which leading toxicologists advocate opposing sides of an issue that has significant toxicological importance. The debate continues a tradition that originated in the early 1990s. This year, the debaters will address the proposition 'Will the exposome drastically change the practice of toxicology?' The debaters will explain the concept of the exposome and discuss its opportunities and challenges for toxicity assessments. Specific questions to be addressed include: Is the exposome concept adequately mature to be applied in the assessment of human toxicities? Is our understanding of what factors contribute to the exposome sufficiently known? Is there a systematic way to measure or model the influence of environmental exposures? Are analytical and diagnostic techniques sufficiently advanced to reliably measure the exposome? Do we have the necessary mechanistic understanding to allow linking exposures with health outcomes? Are we ready to include “all life exposures” in our toxicology practice? Are we able to integrate the social exposome with our toxicology practice? In addition to inclusion as a Featured Session at this meeting, this debate will take place again (with the debaters taking the reverse positions) in Ljubljana, Slovenia, during EUROTOX 2023, September 10–13, 2023.