The Baltimore Social-Environmental Collaborative (BSEC) is a Department of Energy Urban Integrated Field Lab program designed to generate the science needed for informed energy investments and extreme weather resilience in Baltimore. Working with businesses, local and state government representatives, and community organizations, BSEC scientists produce the decision-relevant science needed to address local priorities and needs. As data is gathered and findings discovered, the work evolves to answer questions our partners identify. Vulnerability to extreme heat and to poor air quality—both indoor and outdoor—has been a persistent theme throughout BSEC’s work, with elevated asthma rates in poor neighborhoods identified as a deep concern. Here, I will describe how BSEC research on heat, air quality, and housing conditions is integrated to understand space and time patterns in childhood and adult asthma burden. This work has already revealed neighborhood-scale links between heat and asthma. Continued work that uses diverse air quality measurements, a model of indoor air pollutants, and an analysis of building energy use is designed to support deeper understanding of these patterns and to inform interventions.