We have modelled the global atmosphere and climate across the coming decades for three different policy-relevant scenarios for the European Union’s CATALYSE project (Climate Action to Advance Healthy Societies in Europe). We then estimated the mortality due to air pollution exposure in each of the three scenarios. We find that in a reference scenario, mortality due to air pollution increases by over 86,000 in Europe in 2050 compared to 2020. We also find that CATALYSE’s “Green Deal Scenario”, modelled after the European Green Deal legislation, reduces the 2050 air pollution mortality by over 36,000 lives. The “Beyond Green Deal Scenario”, which goes further than the Green Deal Scenario by implementing behavioural changes to diet and energy use, for example, saves an additional 7,182 lives.