After a major earthquake, smaller earthquakes called aftershocks usually follow. These early aftershocks can help scientists better understand the main earthquake and how stress changes in the Earth’s crust. However, it is difficult to detect early aftershocks because they often overlap with the signals from the main earthquake. In this study, we used advanced tools, including computer-based methods, to look for early aftershocks following moderate earthquakes in the Central and Eastern United States, where earthquakes are less frequent. Because this region has fewer background earthquakes, it offers a unique chance to detect subtle early activity that might be missed in more active areas. We studied earthquakes like 2011 M5.7 Virginia, the 2020 M5.2 Sparta, and 2024 M4.8 New Jersey events. For each case, we built detailed earthquake catalogs using both synthetic simulations and manual analysis. We then estimated the aftershock rate following each event. Our results show that several sequences lack clear early aftershock signals, suggesting a suppression of immediate aftershock activity, possibly due to the relatively low background rates in the regions. These findings help improve our understanding of aftershock behavior in intraplate regions and contribute to more accurate seismic hazard assessments.