Cloud phase transition (from liquid water to ice) is of great importance to Earth's energy and water cycle. Forming ice crystals in mixed-phase clouds requires ice nucleating particles (INPs). However, whether the anthropogenic pollution can be efficient INPs remains unclear. In this study, based on satellite and aircraft observations in China, the temperature when clouds start to freeze is estimated by analyzing the frequency of liquid water and glaciated cloud tops, under which the occurrence of glaciated cloud tops started to overtake that of pure liquid water cloud tops. We found that the clouds over the anthropogenically polluted region over China presented higher freezing temperature than other cleaner regions. The results suggest anthropogenic pollution can efficiently control cloud glaciation in regional scale by serving as INPs.