Methane is a powerful greenhouse gas, and reducing human-caused emissions is one of the fastest ways to slow climate change. MethaneSAT, a satellite that operated from March 2024 to June 2025, collected detailed data on both large leaks from single facilities and smaller leaks spread across many facilities or larger areas. We analyzed 15 satellite observations from two U.S. regions: the Permian Basin and California’s San Joaquin Valley. In the Permian Basin, we estimated total methane emissions of 450 tonnes per hour, mostly from oil and gas activities. In the San Joaquin Valley, we found 120 tonnes per hour, mainly from agriculture and other sources. These results align with other studies and databases. MethaneSAT’s data can help identify major methane sources, track changes over time, and guide emission reduction efforts. This work shows how satellite measurements can improve accountability and support more effective climate solutions.