Vibriosis, a bacterial infection concerning public health, is clearly increasing over time and across locations. This study used computer modeling (Ecological Niche Modeling or ENM) to predict where and when Vibrio bacteria thrive. We tested different ways to make these models, and the Bootstrap method worked best. It was very accurate (scoring 0.97 out of 1.00) and gave consistent results. The most important environmental factors for Vibrio were phosphate, sea surface temperature (SST), and colored dissolved organic matter (CDOM). While CDOM didn't contribute as much to the model's initial training, it was still a critical influence on where Vibrio could live. Vibrio prefers: Warm water (around 25–28°C), Slightly alkaline water (pH around 8.2), Salty marine water (more than 35 PSU), Low phosphate levels, Moderate amounts of CDOM (which suggests clearer water). We also looked at how Vibrio habitats change with seasons. While overall hotspots stayed similar, a model focused on summer months (JJA model) showed much stronger and more concentrated areas of high risk. This means that focusing on specific seasons can help us predict and prevent Vibrio infections more precisely.