Oil and gas operations release not only methane, a potent greenhouse gas, but other health-harming chemicals which can impact the health of nearby communities. Research has typically focused on the climate impacts from methane, but less is known about the co-pollutants released with methane from oil and gas operations. Regulations to limit methane emissions from oil and gas operations exist in places like Colorado and Mexico, but policies may benefit from further understanding of how methane co-pollutants can impact human health. Our research utilizes air quality monitoring data from oil and gas sites in Colorado to better understand the health risks from chemicals released along with methane through use of a cumulative human health risk assessment. We also aim to assess how methane levels may serve as a proxy for the release of other health-relevant co-pollutants.