Hypoxia, defined as dissolved oxygen levels below 2 mg/L, is a recurring environmental challenge in the northern Gulf of Mexico, where nutrient-rich runoff and water column stratification contribute to one of the largest coastal “dead zones” in the world. These low-oxygen conditions threaten marine biodiversity, fisheries, and the sustainability of coastal communities. The goal of this study was to evaluate how dissolved oxygen, chlorophyll-a (as a proxy for algal biomass), and water depth interact to influence the seasonal development and spatial distribution of hypoxia. Multi-year in-situ data from NOAA’s Southeast Area Monitoring and Assessment Program (SEAMAP) and satellite-derived chlorophyll-a imagery were analyzed using GIS-based spatial analysis and statistical tools. Preliminary findings suggest hypoxia is the most severe in deeper, stratified waters during summer months, with strong associations to elevated chlorophyll-a concentrations. By visualizing these trends across space and time, this work offers insights into the environmental dynamics driving hypoxia and provides valuable tools to support management strategies in coastal and marine systems