From participating in the development of the International HapMap and 1000 Genomes projects to the establishment of the African Society of Human Genetics and the Human Heredity and Health in Africa Initiative (H3Africa), the African genomics ecosystem has experienced tremendous growth. The increasing participation of African scientists and communities is transforming human genetics and genomics and is generating profound new insights and capacity to ask novel questions and advance human health. The 2022 Presidential Symposium will highlight this profoundly dynamic and diverse continent's major advances, new directions and goals, emerging scientific leadership, exciting investment in technology infrastructure, and more. How can and will genomics in Africa 'spread its wings' and what areas are most exciting? Join a global community for an exciting dialogue about what African genomics is - and is becoming.